Disrupting HBV Persistence: Genetic Engineering Approach to Break the Oncogenic HBx Gene

Authors

  • Saleha Resham Atta ur Rahman School of Applied Biosciences, National University of Science and Technology (NUST)
  • Haiqa Khan Atta ur Rahman School of Applied Biosciences, National University of Science and Technology (NUST)
  • Fazal Adnan Atta ur Rahman School of Applied Biosciences, National University of Science and Technology (NUST)
  • Sobia Manzoor Atta ur Rahman School of Applied Biosciences, National University of Science and Technology (NUST)

DOI:

https://doi.org/10.24949/njes.v18i1.912

Abstract

Chronic Hepatitis B virus (HBV) infection can cause liver cirrhosis or cancer , making it a persistent worldwide health concern. Nucleoside analogs used in current antiviral treatments can prevent HBV from replicating, but they do not break the covalently closed circular DNA that HBV currently possesses. 

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Published

2025-08-17

Issue

Vol. 18 No. 1 (2025): (In Progress)

Section

Engineering Sciences

License

Copyright (c) 2025 NUST Journal of Engineering Sciences

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This work is licensed under a Creative Commons Attribution 4.0 International License.